Polygenic burden of short tandem repeat expansions promote risk for Alzheimer’s disease

Abstract excerpt

Studies of the genetics of Alzheimer’s disease (AD) have largely focused on single nucleotide variants and short insertions/deletions. However, most of the disease heritability has yet to be uncovered, suggesting that there is substantial genetic risk conferred by other forms of genetic variation. There are over one million short tandem repeats (STRs) in the genome, and their link to AD risk has not been assessed....

Topics

Open a Topic to create a Post that cites this publication.

• Aged, 80 and over
• Alzheimer Disease
• Case-Control Studies
• DNA Repeat Expansion
• Genome-Wide Association Study
• Microsatellite Repeats
• Multifactorial Inheritance
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

01a6d733-b21a-5a5d-8aa3-a879c26a49c2

DOI

10.1101/2023.11.16.23298623