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Article

WNT signalling promotes NF-κB activation and drug resistance in KRAS-mutant colorectal cancer.

EMBO reports - 1 Dec 2025

Cong Bojie, Stamou Evangelia, Pennel Kathryn, Thakur Teena, Mckenzie Molly, Matly Amna, Gilroy Kathryn, Shah Harshit, Gopinath Sindhura, Edwards Joanne, Cagan Ross

Abstract excerpt

Approximately 40% of colorectal cancer (CRC) cases are characterised by KRAS mutations, rendering them insensitive to most therapies. While the reasons for this resistance remain incompletely understood, one key aspect is genetic complexity: in CRC, oncogenic KRAS is most commonly paired with mutations that alter WNT and P53 activities ("RAP"). Here, we demonstrate that elevated WNT activity upregulates canonical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41188521
DOI: 10.1038/s44319-025-00588-1
PMCID: PMC12678608

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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