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WNT Signalling Promotes NF-κB Activation and Drug Resistance in KRAS-Mutant Colorectal Cancer

2023-12-23

Abstract excerpt

Approximately 40% of colorectal cancer (CRC) cases are characterized by KRAS mutations, rendering them insensitive to most CRC therapies. While the reasons for this resistance remain incompletely understood, one key aspect is genetic complexity: in CRC, oncogenic KRAS is most commonly paired with mutations that alter WNT and P53 activities (“RAP”). Here, we demonstrate that elevated WNT activity upregulates canoni...

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Literature Corpus work
b2344a21-c7bf-5d73-ad58-5f599cdf837d
DOI
10.1101/2023.12.21.572810
Open publication

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WNT Signalling Promotes NF-κB Activation and Drug Resistance in KRAS-Mutant Colorectal CancerDOI 10.1101/2023.12.21.572810
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