Interplay between WNT/PI3K-mTOR axis and the microbiota in APC-driven colorectal carcinogenesis: data from a pilot study and possible implications for CRC prevention.

doi:10.1186/s12967-024-05305-5

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Article

Interplay between WNT/PI3K-mTOR axis and the microbiota in APC-driven colorectal carcinogenesis: data from a pilot study and possible implications for CRC prevention.

Journal of translational medicine - 5 Jul 2024

Di Paola Floriana Jessica, Alquati Chiara, Conti Gabriele, Calafato Giulia, Turroni Silvia, D'Amico Federica, Ceccarelli Claudio, Buttitta Francesco, Bernardi Alice, Cuicchi Dajana, Poggioli Gilberto, Turchetti Daniela, Ferrari Simona, Cannizzaro Renato, Realdon Stefano, Brigidi Patrizia, Ricciardiello Luigi

Abstract excerpt

BACKGROUND: Wnt/β-catenin signalling impairment accounts for 85% of colorectal cancers (CRCs), including sporadic and familial adenomatous polyposis (FAP) settings. An altered PI3K/mTOR pathway and gut microbiota also contribute to CRC carcinogenesis. We studied the interplay between the two pathways and the microbiota composition within each step of CRC carcinogenesis. METHODS: Proteins and target genes of both...

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PMID: 38970018
DOI: 10.1186/s12967-024-05305-5
PMCID: PMC11227240

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