Article
Wnt Signaling and Drug Resistance in Cancer.
Molecular pharmacology - 1 Feb 2020
Zhong Zheng, Virshup David M
Abstract excerpt
Wnts are secreted proteins that bind to cell surface receptors to activate downstream signaling cascades. Normal Wnt signaling plays key roles in embryonic development and adult tissue homeostasis. The secretion of Wnt ligands, the turnover of Wnt receptors, and the signaling transduction are tightly regulated and fine-tuned to keep the signaling output "just right." Hyperactivated Wnt signaling due to recurrent...
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