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Article

Targeting the Wnt signaling pathway in colorectal cancer.

Expert opinion on therapeutic targets - 1 Jan 2016

Sawa Masaaki, Masuda Mari, Yamada Tesshi

Abstract excerpt

INTRODUCTION: The treatment of patients with advanced colorectal cancer still remains challenging, and identification of new target molecules and therapeutic avenues remains a priority. The great majority of colorectal cancers have mutations in one of two genes involved in the Wnt signaling pathway: the adenomatous polyposis coli (APC) and β-catenin (CTNNB1) genes. Up to now, however, no therapeutics for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26439805
DOI: 10.1517/14728222.2016.1098619

Genes

APC
TNIK
CTNNB1
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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