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Article

Negative prognostic impact of Co-mutations in TGFβ and TP53 pathways in surgically resected rectal tumors following neoadjuvant chemoradiotherapy.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Apr 2024

Qian Chengyuan, Yang Weina, Li Mengxia, Feng Yan, Dai Nan, Luo Hao, Jian Dan, Li Xuemei, Yang Yuxin, He Yue, Wang Dong, Li Chunxue, Xiao He

Abstract excerpt

BACKGROUND: Preoperative neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME) is a common approach for treating patients with locally advanced rectal cancer. Nevertheless, the mutational profile and its prognostic impact in surgically resected tumor specimens after nCRT remains to be clarified. METHODS: The comprehensive analysis of mutational landscape was retrospectively conducted by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Rectal Neoplasms

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Source

Identifiers

PMID: 38460248
DOI: 10.1016/j.ejso.2024.108242

Genes

TP53
APC
KRAS
PIK3CA
TRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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