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Article

Colon cancer cells evade drug action by enhancing drug metabolism

10 Jul 2025

Abstract excerpt

Abstract Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide. One key reason is the lack of durable therapies that target KRAS-dependent disease, which represents approximately 40% of CRC cases. Here, we use liquid chromatography/mass spectrometry (LC/MS) analyses on Drosophila CRC tumour models to identify multiple metabolites in the glucuronidation pathway—a toxin clearance pathway...

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PMID: 40634495
DOI: 10.1038/s41388-025-03472-3

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