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Article

Construction of a complete set of Neisseria meningitidis mutants and its use for the phenotypic profiling of this human pathogen.

Nature communications - 2 Nov 2020

Muir Alastair, Gurung Ishwori, Cehovin Ana, Bazin Adelme, Vallenet David, Pelicic Vladimir

Abstract excerpt

The bacterium Neisseria meningitidis causes life-threatening meningitis and sepsis. Here, we construct a complete collection of defined mutants in protein-coding genes of this organism, identifying all genes that are essential under laboratory conditions. The collection, named NeMeSys 2.0, consists of individual mutants in 1584 non-essential genes. We identify 391 essential genes, which are associated with basic...

Topics

Bacterial Proteins
Computational Biology
Fimbriae Proteins
Fimbriae, Bacterial
Gene Expression Profiling
Gene Expression Regulation, Bacterial
Genes, Bacterial
Genes, Essential
Genome, Bacterial
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neisseria meningitidis

Phenotype

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Open in PubMed Open full text

Identifiers

PMID: 33139723
DOI: 10.1038/s41467-020-19347-y
PMCID: PMC7606547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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