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Article

Construction of a complete set of Neisseria meningitidis mutants and its use for the phenotypic profiling of this human pathogen.

Nature communications - 2 Nov 2020

Muir Alastair, Gurung Ishwori, Cehovin Ana, Bazin Adelme, Vallenet David, Pelicic Vladimir

Abstract excerpt

The bacterium Neisseria meningitidis causes life-threatening meningitis and sepsis. Here, we construct a complete collection of defined mutants in protein-coding genes of this organism, identifying all genes that are essential under laboratory conditions. The collection, named NeMeSys 2.0, consists of individual mutants in 1584 non-essential genes. We identify 391 essential genes, which are associated with basic...

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Identifiers

PMID: 33139723
DOI: 10.1038/s41467-020-19347-y
PMCID: PMC7606547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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