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Mechanistic and clinical insights into a PmrB mutation driving colistin resistance and virulence in Acinetobacter baumannii.

Scientific reports - 30 Jan 2026

Bazyar Kimia, Jamali Pariya, Kalantar Kiana, Hedayatdoust Hasti, Amini Kumarss

Abstract excerpt

The global rise of colistin-resistant Acinetobacter baumannii (CRAB) is a critical health threat, particularly in the Middle East. The pmrB c.235T > A (p.Leu79Ile) mutation is frequently observed in clinical isolates, but its comprehensive characterization is lacking. In this multicenter study, 465 clinical A. baumannii isolates were collected from Iran (n = 378) and Iraq (n = 87) between January 2023 and June...

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PMID: 41617754
DOI: 10.1038/s41598-025-33812-y
PMCID: PMC12864739

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