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Article

Experimental evolution in morbidostat reveals converging genomic trajectories on the path to triclosan resistance.

Microbial genomics - 1 May 2021

Leyn Semen A, Zlamal Jaime E, Kurnasov Oleg V, Li Xiaoqing, Elane Marinela, Myjak Lourdes, Godzik Mikolaj, de Crecy Alban, Garcia-Alcalde Fernando, Ebeling Martin, Osterman Andrei L

Abstract excerpt

Understanding the dynamics and mechanisms of acquired drug resistance across major classes of antibiotics and bacterial pathogens is of critical importance for the optimization of current anti-infective therapies and the development of novel ones. To systematically address this challenge, we developed a workflow combining experimental evolution in a morbidostat continuous culturing device with deep genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33945454
DOI: 10.1099/mgen.0.000553
PMCID: PMC8209735

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