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Article

Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-Negative Bacterial Pathogens.

mBio - 29 Jun 2021

Zlamal Jaime E, Leyn Semen A, Iyer Mallika, Elane Marinela L, Wong Nicholas A, Wamsley James W, Vercruysse Maarten, Garcia-Alcalde Fernando, Osterman Andrei L

Abstract excerpt

Resistance to the broad-spectrum antibiotic ciprofloxacin is detected at high rates for a wide range of bacterial pathogens. To investigate the dynamics of ciprofloxacin resistance development, we applied a comparative resistomics workflow for three clinically relevant species of Gram-negative bacteria: Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa. We combined experimental evolution in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34154405
DOI: 10.1128/mBio.00987-21
PMCID: PMC8262867

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