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Article

Genome-Wide Association Study of Susceptibility Loci for TCF3-PBX1 Acute Lymphoblastic Leukemia in Children.

Journal of the National Cancer Institute - 1 Jul 2021

Lee Shawn H R, Qian Maoxiang, Yang Wentao, Diedrich Jonathan D, Raetz Elizabeth, Yang Wenjian, Dong Qian, Devidas Meenakshi, Pei Deqing, Yeoh Allen, Cheng Cheng, Pui Ching-Hon, Evans William E, Mullighan Charles G, Hunger Stephen P, Savic Daniel, Relling Mary V, Loh Mignon L, Yang Jun J

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common cancer in children. TCF3-PBX1 fusion defines a common molecular subtype of ALL with unique clinical features, but the molecular basis of its inherited susceptibility is unknown. In a genome-wide association study of 1494 ALL cases and 2057 non-ALL controls, we identified a germline risk locus located in an intergenic region between BCL11A and PAPOLG:...

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Share to Basic Helix-Loop-Helix Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

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Identifiers

PMID: 32882024
DOI: 10.1093/jnci/djaa133
PMCID: PMC8487647

Genes

PBX1
TCF3
BCL11A
PAPOLG
REL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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