Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility.

doi:10.1371/journal.pone.0180488

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Article

Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility.

PloS one - 1 Jan 2017

Archer Natalie P, Perez-Andreu Virginia, Stoltze Ulrik, Scheurer Michael E, Wilkinson Anna V, Lin Ting-Nien, Qian Maoxiang, Goodings Charnise, Swartz Michael D, Ranjit Nalini, Rabin Karen R, Peckham-Gregory Erin C, Plon Sharon E, de Alarcon Pedro A, Zabriskie Ryan C, Antillon-Klussmann Federico, Najera Cesar R, Yang Jun J, Lupo Philip J

Abstract excerpt

We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more commonly used case-control studies, this study design is ideal for avoiding issues with population stratification bias among this at-risk ethnic group. Using 710...

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PMID: 28817678
DOI: 10.1371/journal.pone.0180488
PMCID: PMC5560704

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