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Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in <i>Drosophila melanogaster</i>

2022-01-31

Abstract excerpt

Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and regulates numerous aspects of genome organization and function. Loss-of-function mutations in Drosophila melanogaster Set8 or mammalian KMT5A prevent H4K20me1 and disrupt development. Set8/KMT5A also has non-histone substrates, making it difficult to determine which developmental functions of Set8/KMT5A are attributable to H4K20me...

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Literature Corpus work
e2d5341b-4856-5f6c-9693-fc9d0e7aa74d
DOI
10.1101/2022.01.30.478405
Open publication

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Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in <i>Drosophila melanogaster</i>DOI 10.1101/2022.01.30.478405
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