SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity.

doi:10.1038/s41594-021-00712-4

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Article

SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity.

Nature structural & molecular biology - 1 Feb 2022

Delaney Colin E, Methot Stephen P, Kalck Veronique, Seebacher Jan, Hess Daniel, Gasser Susan M, Padeken Jan

Abstract excerpt

Transcriptionally silenced heterochromatin bearing methylation of histone H3 on lysine 9 (H3K9me) is critical for maintaining organismal viability and tissue integrity. Here we show that in addition to ensuring H3K9me, MET-2, the Caenorhabditis elegans homolog of the SETDB1 histone methyltransferase, has a noncatalytic function that contributes to gene repression. Subnuclear foci of MET-2 coincide with H3K9me...

Topics

Animals
Animals, Genetically Modified
Biocatalysis
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Chromosomal Proteins, Non-Histone
Gene Silencing
Heterochromatin
Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histones

Intrinsically Disordered Proteins

Methylation

Models, Biological

Mutation

Transcription, Genetic

Source

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Identifiers

PMID: 35102319
DOI: 10.1038/s41594-021-00712-4
PMCID: PMC8850192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-35102319-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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