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Article

SUMO-mediated regulation of H3K4me3 reader SET-26 controls germline development in C. elegans.

PLoS biology - 1 Jan 2025

Carvalho Cátia A, Abu-Shach Ulrike Bening, Raju Asha, Vershinin Zlata, Levy Dan, Boxem Mike, Broday Limor

Abstract excerpt

Sumoylation is a posttranslational modification essential for multiple cellular functions in eukaryotes. ULP-2 is a conserved SUMO protease required for embryonic development in Caenorhabditis elegans. Here, we revealed that ULP-2 controls germline development by regulating the PHD-SET domain protein, SET-26. Specifically, loss of ULP-2 results in sterility and a progressive elevation of global protein...

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Identifiers

PMID: 39761316
DOI: 10.1371/journal.pbio.3002980
PMCID: PMC11703099

Genes

SET

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SUMO-mediated regulation of H3K4me3 reader SET-26 controls germline development in C. elegans.PMID 39761316Read ↗

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