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Article

Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster.

Genetics - 31 May 2022

Crain Aaron T, Klusza Stephen, Armstrong Robin L, Santa Rosa Priscila, Temple Brenda R S, Strahl Brian D, McKay Daniel J, Matera A Gregory, Duronio Robert J

Abstract excerpt

Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and regulates numerous aspects of genome organization and function. Loss-of-function mutations in Drosophila melanogaster Set8 or mammalian KMT5A prevent H4K20me1 and disrupt development. Set8/KMT5A also has non-histone substrates, making it difficult to determine which developmental functions of Set8/KMT5A are attributable to H4K20me1...

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Identifiers

PMID: 35404465
DOI: 10.1093/genetics/iyac054
PMCID: PMC9157153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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