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Article

Exploration of novel mechanisms of azole resistance in Candida auris.

Antimicrobial agents and chemotherapy - 5 Dec 2024

Li Jizhou, Brandalise Danielle, Coste Alix T, Sanglard Dominique, Lamoth Frederic

Abstract excerpt

Candida auris is a pathogenic yeast of particular concern because of its ability to cause nosocomial outbreaks of invasive candidiasis (IC) and to develop resistance to all current antifungal drug classes. Most C. auris clinical isolates are resistant to fluconazole, an azole drug that is used for the treatment of IC. Azole resistance may arise from diverse mechanisms, such as mutations of the target gene (ERG11)...

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Antifungal Agents
Azoles
Candidiasis
Cytochrome P-450 Enzyme System
Drug Resistance, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fungal Proteins

Microbial Sensitivity Tests

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Identifiers

PMID: 39480072
DOI: 10.1128/aac.01265-24
PMCID: PMC11619343

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