Article
Precise genome editing underlines the distinct contributions of mutations in ERG11, ERG3, MRR1, and TAC1 genes to antifungal resistance in Candida parapsilosis.
Antimicrobial agents and chemotherapy - 5 Jun 2024
Hartuis Sophie, Ourliac-Garnier Isabelle, Robert Estelle, Albassier Marjorie, Duchesne Léa, Beaufils Clara, Kuhn Joséphine, Le Pape Patrice, Morio Florent
Abstract excerpt
Candida parapsilosis has recently emerged as a major threat due to the worldwide emergence of fluconazole-resistant strains causing clonal outbreaks in hospitals and poses a therapeutic challenge due to the limited antifungal armamentarium. Here, we used precise genome editing using CRISPR-Cas9 to gain further insights into the contribution of mutations in ERG11, ERG3, MRR1, and TAC1 genes and the influence of...
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