Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance.

Microbiology spectrum - 22 Dec 2021

Rybak Jeffrey M, Sharma Cheshta, Doorley Laura A, Barker Katherine S, Palmer Glen E, Rogers P David

Abstract excerpt

Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele in a previously characterized fluconazole-susceptible clinical isolate was replaced with the ERG11 alleles from three highly fluconazole-resistant clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Candidiasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Drug Resistance, Fungal

Share to Fluconazole

Share to Fungal Proteins

Share to Microbial Sensitivity Tests

Share to Triazoles

Source

Open in PubMed Open full text

Identifiers

PMID: 34878305
DOI: 10.1128/Spectrum.01585-21
PMCID: PMC8653815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance.PMID 34878305Read ↗

Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris.Semantic proximity Read ↗

Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates.Semantic proximity Read ↗

Mutations in TAC1 and ERG11 are major drivers of triazole antifungal resistance in clinical isolates of Candida parapsilosis.Semantic proximity Read ↗

Mutations in <i>TAC1B</i> : a novel genetic determinant of clinical fluconazole resistance in <i>C. auris</i>Semantic proximity Read ↗

Precise genome editing underlines the distinct contributions of mutations in ERG11, ERG3, MRR1, and TAC1 genes to antifungal resistance in Candida parapsilosis.Semantic proximity Read ↗

Relative contributions of the <i>ERG11</i> <sup>VF125AL</sup> and <i>MRR1A</i> <sup>N647T</sup> mutations to fluconazole resistance in Clade III <i>Candidozyma</i> ( <i>Candida</i> ) <i>auris</i> clinical isolatesSemantic proximity Read ↗

Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility.Semantic proximity Read ↗

A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance.Semantic proximity Read ↗

Exploration of novel mechanisms of azole resistance in Candida auris.Semantic proximity Read ↗

Deciphering the multidrug resistance paradigm in Candida auris.Semantic proximity Read ↗

Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In VivoSemantic proximity Read ↗

Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.