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Article

TCR signal-enhancing mutation alters lipid metabolism of thymocytes and impairs antitumor immunity of mature T cells.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2025

Liang Wenhua, Liang Yuge, Yu Mingzhu, Ji Chenshuang, Wang Feng

Abstract excerpt

The T cell receptor (TCR), a master regulator of adaptive immunity, serves as a molecular transducer that converts antigen recognition into precisely modulated intracellular signals, orchestrating both T cell development and effector functions. In this study, we leveraged a germline CD3εI173A mutation, a previously characterized alteration that amplifies TCR signaling through the disruption of inhibitory lipid...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41100674
DOI: 10.1073/pnas.2507154122
PMCID: PMC12557506

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