Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments.

doi:10.1038/s41590-020-00848-3

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Article

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments.

Nature immunology - 1 Feb 2021

Lopes Noella, McIntyre Claire, Martin Stefania, Raverdeau Mathilde, Sumaria Nital, Kohlgruber Ayano C, Fiala Gina J, Agudelo Leandro Z, Dyck Lydia, Kane Harry, Douglas Aaron, Cunningham Stephen, Prendeville Hannah, Loftus Roisin, Carmody Colleen, Pierre Philippe, Kellis Manolis, Brenner Michael, Argüello Rafael J, Silva-Santos Bruno, Pennington Daniel J, Lynch Lydia

Abstract excerpt

Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-17 have intrinsically distinct metabolic requirements. Whereas IFN-γ+ γδ T cells were almost exclusively dependent on glycolysis, IL-17+ γδ T cells strongly engaged oxidative metabolism, with increased...

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PMID: 33462452
DOI: 10.1038/s41590-020-00848-3
PMCID: PMC7610600

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