Article

Transcriptomes and metabolism define mouse and human MAIT cell heterogeneity

2021-12-21

Abstract excerpt

Mucosal-associated invariant T (MAIT) cells are a subpopulation of T lymphocytes that respond to microbial metabolites. We performed single-cell RNA sequencing and metabolic analyses of MAIT cell subsets in thymus and peripheral tissues from mice and humans to define the heterogeneity and developmental pathway of these innate-like lymphocytes. We show that the predominant mouse subset, which produces IL-17 (MAIT17...

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Literature Corpus work: f893ce6d-60d6-5c3a-9048-de474212ed73
DOI: 10.1101/2021.12.20.473182

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