Article

Spatial cholesterol homeostasis gatekeeps T-cell development and activation by orchestrating signaling and fitness

2026-08-20

Abstract excerpt

<h4>ABSTRACT</h4> Cholesterol is essential for T-cell immunity, and its spatial distribution is tightly regulated. Although cholesterol is synthesized in the endoplasmic reticulum (ER), it is predominantly transported to the plasma membrane (PM); however, the machinery mediating this anterograde transport in T cells remains unknown. Here, through a functional genetic screen, we identify oxysterol-binding protein...

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Literature Corpus work: ce0c11d4-6834-5535-8c26-5003fb1c1155
DOI: 10.64898/2026.08.16.745088

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