Article
Distinguishing specific from broad genetic associations between external correlates and common factors.
Bioinformatics (Oxford, England) - 1 Nov 2025
de la Fuente Javier, Londoño-Correa Diego, Tucker-Drob Elliot M
Abstract excerpt
MOTIVATION: Within the genomic structural equation modelling (genomic SEM) framework, common factors are often used to index shared genetic etiology across constellations of genome-wide associations studies (GWASs) phenotypes. A standard common pathway model, in which a genetic association is estimated between an external GWAS phenotype and a common factor, assumes that all genetic associations between the...
Read the complete abstract on PubMedTopics
- Genome-Wide Association Study
- Humans
- Algorithms
- Models, Genetic
- Phenotype
- Alzheimer Disease
- Polymorphism, Single Nucleotide