Distinguishing Specific from Broad Genetic Associations between External Correlates and Common Factors

Abstract excerpt

Within the Genomic SEM framework, common factors are often used to index shared genetic etiology across constellations of GWAS phenotypes. A standard common pathway model, in which a genetic association is estimated between an external GWAS phenotype and a common factor, assumes that all genetic associations between the external GWAS phenotype and the individual indicator phenotypes are mediated through the factor...

Topics

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• Comorbidity
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Genomics
• Latent Class Analysis
• Multifactorial Inheritance
• Phenotype
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

c41c41d9-4a77-50c1-bc9c-09285bc4ec1b

DOI

10.1101/2025.06.02.657362