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Article

A multivariate approach to understanding the genetic overlap between externalizing phenotypes and substance use disorders.

Addiction biology - 1 Sept 2023

Poore Holly E, Hatoum Alexander, Mallard Travis T, Sanchez-Roige Sandra, Waldman Irwin D, Palmer Abraham A, Harden K Paige, Barr Peter B, Dick Danielle M

Abstract excerpt

Substance use disorders (SUDs) are phenotypically and genetically correlated with each other and with other psychological traits characterized by behavioural under-control, termed externalizing phenotypes. In this study, we used genomic structural equation modelling to explore the shared genetic architecture among six externalizing phenotypes and four SUDs used in two previous multivariate genome-wide association...

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Source

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Identifiers

PMID: 37644899
DOI: 10.1111/adb.13319
PMCID: PMC11010459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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