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Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology.

Psychological medicine - 8 May 2025

Davis Christal N, Khan Yousef, Toikumo Sylvanus, Jinwala Zeal, Boomsma Dorret I, Levey Daniel F, Gelernter Joel, Kember Rachel L, Kranzler Henry R

Abstract excerpt

BACKGROUND: There is considerable comorbidity between externalizing (EXT) and internalizing (INT) psychopathology. Understanding the shared genetic underpinnings of these spectra is crucial for advancing knowledge of their biological bases and informing empirical models like the Research Domain Criteria (RDoC) and Hierarchical Taxonomy of Psychopathology (HiTOP). METHODS: We applied genomic structural equation...

Topics

Humans
Genome-Wide Association Study
Mental Disorders
Male
Female
Adult
Psychopathology
Comorbidity
Major Depressive Disorder
Latent Class Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

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Open in PubMed Open full text

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PMID: 40336358
DOI: 10.1017/S0033291725000856
PMCID: PMC12094639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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