Article

Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing Psychopathology

2024-04-09

Abstract excerpt

<h4>Background</h4> There is considerable comorbidity between externalizing (EXT) and internalizing (INT) psychopathology. Understanding the shared genetic underpinnings of these spectra is crucial for advancing knowledge of their biological bases and informing empirical models like the Research Domain Criteria (RDoC) and Hierarchical Taxonomy of Psychopathology (HiTOP). <h4>Methods</h4> We applied genomic structu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b21a107-db43-50ea-be0d-b928de94c502
DOI: 10.1101/2024.04.06.24305166

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing PsychopathologyDOI 10.1101/2024.04.06.24305166Read

Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology.Semantic proximity Read

A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology SpectraSemantic proximity Read

Testing structural models of psychopathology at the genomic levelSemantic proximity Read

Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing PsychopathologySemantic proximity Read

Disentangling differing relationships between internalizing disorders and alcohol use.Semantic proximity Read

Genetic Liability for Internalizing–Externalizing Traits in Mexican Youth: Moderation by AdversitySemantic proximity Read

Parsing Genetically Influenced Risk Pathways: Genetic Loci Impact Problematic Alcohol Use Via Externalizing and Specific RiskSemantic proximity Read

A multivariate approach to understanding the genetic overlap between externalizing phenotypes and substance use disorders.Semantic proximity Read

The boundaries of the internalizing and externalizing genetic spectra in men and women.Semantic proximity Read

A Family-Based Genome Wide Association Study of Externalizing Behaviors.Semantic proximity Read

Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex.Semantic proximity Read

Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk.Semantic proximity Read