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SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits.

Genome biology - 7 Sept 2021

Zhang Yiliang, Lu Qiongshi, Ye Yixuan, Huang Kunling, Liu Wei, Wu Yuchang, Zhong Xiaoyuan, Li Boyang, Yu Zhaolong, Travers Brittany G, Werling Donna M, Li James J, Zhao Hongyu

Abstract excerpt

Local genetic correlation quantifies the genetic similarity of complex traits in specific genomic regions. However, accurate estimation of local genetic correlation remains challenging, due to linkage disequilibrium in local genomic regions and sample overlap across studies. We introduce SUPERGNOVA, a statistical framework to estimate local genetic correlations using summary statistics from genome-wide...

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Identifiers

PMID: 34493297
DOI: 10.1186/s13059-021-02478-w
PMCID: PMC8422619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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