Article

Parsing Genetically Influenced Risk Pathways: Genetic Loci Impact Problematic Alcohol Use Via Externalizing and Specific Risk

2021-07-23

Abstract excerpt

<h4>Importance</h4> Characterizing whether genetic variants for psychiatric outcomes operate via specific versus general pathways provides more informative measures of genetic risk, and, potentially, allows us to design more targeted prevention and interventions. <h4>Objective</h4> Employ multivariate methods to tease apart variants associated with problematic alcohol use through either general or specific pathway...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 945f8223-8ea3-52c3-bd38-923ed2c51a8c
DOI: 10.1101/2021.07.20.21260861

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Parsing Genetically Influenced Risk Pathways: Genetic Loci Impact Problematic Alcohol Use Via Externalizing and Specific RiskDOI 10.1101/2021.07.20.21260861Read

Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk.Semantic proximity Read

A Family-Based Genome Wide Association Study of Externalizing Behaviors.Semantic proximity Read

A multivariate approach to understanding the genetic overlap between externalizing phenotypes and substance use disorders.Semantic proximity Read

Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing PsychopathologySemantic proximity Read

Clinical, Environmental, and Genetic Risk Factors for Substance Use Disorders: Characterizing Combined Effects across Multiple CohortsSemantic proximity Read

Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology.Semantic proximity Read

Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study.Semantic proximity Read

A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology SpectraSemantic proximity Read

Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts.Semantic proximity Read

Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples.Semantic proximity Read

The Genetics of Externalizing Problems.Semantic proximity Read