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Article

Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk.

Translational psychiatry - 30 Sept 2022

Barr Peter B, Mallard Travis T, Sanchez-Roige Sandra, Poore Holly E, Linnér Richard Karlsson, Waldman Irwin D, Palmer Abraham A, Harden K Paige, Dick Danielle M

Abstract excerpt

Genome-wide association studies (GWAS) identify genetic variants associated with a trait, regardless of how those variants are associated with the outcome. Characterizing whether variants for psychiatric outcomes operate via specific versus general pathways provides more informative measures of genetic risk. In the current analysis, we used multivariate GWAS to tease apart variants associated with problematic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36180423
DOI: 10.1038/s41398-022-02171-x
PMCID: PMC9525649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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