Article
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation.
Nature genetics - 1 Dec 2013
Guo Guangwu, Sun Xiaojuan, Chen Chao, Wu Song, Huang Peide, Li Zesong, Dean Michael, Huang Yi, Jia Wenlong, Zhou Quan, Tang Aifa, Yang Zuoquan, Li Xianxin, Song Pengfei, Zhao Xiaokun, Ye Rui, Zhang Shiqiang, Lin Zhao, Qi Mingfu, Wan Shengqing, Xie Liangfu, Fan Fan, Nickerson Michael L, Zou Xiangjun, Hu Xueda, Xing Li, Lv Zhaojie, Mei Hongbin, Gao Shengjie, Liang Chaozhao, Gao Zhibo, Lu Jingxiao, Yu Yuan, Liu Chunxiao, Li Lin, Fang Xiaodong, Jiang Zhimao, Yang Jie, Li Cailing, Zhao Xin, Chen Jing, Zhang Fang, Lai Yongqi, Lin Zheguang, Zhou Fangjian, Chen Hao, Chan Hsiao Chang, Tsang Shirley, Theodorescu Dan, Li Yingrui, Zhang Xiuqing, Wang Jian, Yang Huanming, Gui Yaoting, Wang Jun, Cai Zhiming
Abstract excerpt
Bladder cancer is one of the most common cancers worldwide, with transitional cell carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by both whole-genome and whole-exome sequencing of 99 individuals with TCC. Beyond confirming recurrent mutations in genes previously identified as being mutated in TCC, we identified additional altered genes and pathways that were implicated in...
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