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Article

Genetic architecture of quantitative traits and complex diseases.

Current opinion in genetics & development - 1 Dec 2013

Fu Wenqing, O'Connor Timothy D, Akey Joshua M

Abstract excerpt

More than 150 years after Mendel discovered the laws of heredity, the genetic architecture of phenotypic variation remains elusive. Here, we discuss recent progress in deciphering how genotypes map onto phenotypes, sources of genetic complexity, and how model organisms are illuminating general principles about the relationship between genetic and phenotypic variation. Moreover, we highlight insights gleaned from...

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Identifiers

PMID: 24287334
DOI: 10.1016/j.gde.2013.10.008
PMCID: PMC6764439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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