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Article

Widespread signatures of natural selection across human complex traits and functional genomic categories.

Nature communications - 19 Feb 2021

Zeng Jian, Xue Angli, Jiang Longda, Lloyd-Jones Luke R, Wu Yang, Wang Huanwei, Zheng Zhili, Yengo Loic, Kemper Kathryn E, Goddard Michael E, Wray Naomi R, Visscher Peter M, Yang Jian

Abstract excerpt

Understanding how natural selection has shaped genetic architecture of complex traits is of importance in medical and evolutionary genetics. Bayesian methods have been developed using individual-level GWAS data to estimate multiple genetic architecture parameters including selection signature. Here, we present a method (SBayesS) that only requires GWAS summary statistics. We analyse data for 155 complex traits (n...

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Identifiers

PMID: 33608517
DOI: 10.1038/s41467-021-21446-3
PMCID: PMC7896067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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