Article

Mutation-selection-drift balance models of complex diseases

2025-05-18

Abstract excerpt

Genetic variation that influences complex disease susceptibility is introduced into the population by mutation and removed by natural selection and genetic drift. This mutation-selection-drift-balance (MSDB) shapes the prevalence of a disease and its genetic architecture. To date, however, MSDB has only been modeled for monogenic (Mendelian) diseases. Here, we develop a MSDB model for complex disease susceptibilit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a921c9f-c077-57fe-b8c8-d6d975064319
DOI: 10.1101/2025.05.18.654722

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutation-selection-drift balance models of complex diseasesDOI 10.1101/2025.05.18.654722Read

Mutation-selection-drift balance models of complex diseases.Semantic proximity Read

Are rare variants responsible for susceptibility to complex diseases?Semantic proximity Read

Simple scaling laws control the genetic architectures of human complex traitsSemantic proximity Read

Rare variants drive high variance in human ancestral fitness at mutation-selection-drift balanceSemantic proximity Read

Population genetics models of common diseases.Semantic proximity Read

Population genetics of rare variants and complex diseases.Semantic proximity Read

A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk.Semantic proximity Read

The population genetics of human disease: the case of recessive, lethal mutationsSemantic proximity Read

A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets.Semantic proximity Read

Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies.Semantic proximity Read

Genetic association data are broadly consistent with stabilizing selection shaping human common diseases and traitsSemantic proximity Read

Genetic drift from the out-of-Africa bottleneck leads to biased estimation of genetic architecture and selectionSemantic proximity Read