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Article

Mutations and Evolution of the SARS-CoV-2 Spike Protein.

Viruses - 19 Mar 2022

Magazine Nicholas, Zhang Tianyi, Wu Yingying, McGee Michael C, Veggiani Gianluca, Huang Weishan

Abstract excerpt

The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis of new SARS-CoV-2 variants with greatly enhanced overall fitness. Given the trend of variants with increased fitness arising from spike protein alterations, it...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35337047
DOI: 10.3390/v14030640
PMCID: PMC8949778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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