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Mutations and Evolution of the SARS-CoV-2 Spike Protein.

Viruses - 19 Mar 2022

Magazine Nicholas, Zhang Tianyi, Wu Yingying, McGee Michael C, Veggiani Gianluca, Huang Weishan

Abstract excerpt

The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis of new SARS-CoV-2 variants with greatly enhanced overall fitness. Given the trend of variants with increased fitness arising from spike protein alterations, it...

Topics

COVID-19
Humans
Membrane Glycoproteins
Mutation
SARS-CoV-2
Spike Glycoprotein, Coronavirus
Viral Envelope Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35337047
DOI: 10.3390/v14030640
PMCID: PMC8949778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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