Article

The impact of Spike mutations on SARS-CoV-2 neutralization

2021-01-19

Abstract excerpt

Multiple SARS-CoV-2 vaccines have shown protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the viral entry protein, Spike. Antibodies from SARS-CoV-2 infection neutralize the virus by focused targeting of Spike and there is limited serum cross-neutralization of the closely-related SARS-CoV. As new SARS-CoV-2 variants are rapidly emerging, exemplified by the B.1.1.7, 501Y.V2 a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 63f17b66-0a7c-56e2-b9ec-0ca72f83a05f
DOI: 10.1101/2021.01.15.426849

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The impact of Spike mutations on SARS-CoV-2 neutralizationDOI 10.1101/2021.01.15.426849Read

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants.Semantic proximity Read

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variantsSemantic proximity Read

SARS-CoV-2 Variant B.1.1.7 is Susceptible to Neutralizing Antibodies Elicited by Ancestral Spike VaccinesSemantic proximity Read

SARS-CoV-2 variants, spike mutations and immune escape.Semantic proximity Read

Key Substitutions in the Spike Protein of SARS-CoV-2 Variants Can Predict Resistance to Monoclonal Antibodies, but Other Substitutions Can Modify the Effects.Semantic proximity Read

Impact of mutations in SARS-COV-2 spike on viral infectivity and antigenicity.Semantic proximity Read

Mutations and Evolution of the SARS-CoV-2 Spike Protein.Semantic proximity Read

Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effectsSemantic proximity Read

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies.Semantic proximity Read

Research progress in spike mutations of SARS-CoV-2 variants and vaccine development.Semantic proximity Read

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike.Semantic proximity Read

Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants.Semantic proximity Read