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Insertion in the N-Terminal Domain of the SARS-CoV-2 Spike Glycoprotein Affects Antibody Recognition and Phenotypic Properties.

Viruses - 24 Feb 2026

Ermolaeva Elena A, Zyrina Anna N, Sirazova Dina I, Lunin Alexander S, Motov Anton S, Chernavtseva Anastasia D, Gancharova Olga S, Kozlovskaya Liubov I, Shishova Anna A, Siniugina Alexandra A, Ishmukhametov Aydar A

Abstract excerpt

SARS-CoV-2, which causes COVID-19, continues to circulate around the world, making it necessary to study the impact of rapidly emerging mutations on escape from neutralizing antibodies and pathogenesis. While RBD mutations are well characterized, mutations in the N-terminal domain (NTD) of the spike protein remain comparatively understudied despite their relevance to antibody recognition. This study investigates...

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Antibodies, Neutralizing
Antibodies, Viral
Chlorocebus aethiops
Immune Evasion
Protein Domains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 41902185
DOI: 10.3390/v18030277
PMCID: PMC13030607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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