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Article

SARS-CoV-2 variants, spike mutations and immune escape.

Nature reviews. Microbiology - 1 Jul 2021

Harvey William T, Carabelli Alessandro M, Jackson Ben, Gupta Ravindra K, Thomson Emma C, Harrison Ewan M, Ludden Catherine, Reeve Richard, Rambaut Andrew, Peacock Sharon J, Robertson David L

Abstract excerpt

Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome are expected to be either deleterious and swiftly purged or relatively neutral, a small proportion will affect functional properties and may alter infectivity, disease severity or interactions with host immunity. The emergence of SARS-CoV-2 in late 2019 was followed by a period of relative evolutionary stasis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34075212
DOI: 10.1038/s41579-021-00573-0
PMCID: PMC8167834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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