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Article

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.

Nature medicine - 1 Nov 2021

Abstract excerpt

Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human genome to estimate the risk of a disease or disease-related trait for an individual. The potential benefits of PRSs include cost-effective enhancement of primary disease prevention, more refined diagnoses and improved precision when prescribing medicines. However, these must be weighed against the potential risks, such as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34782789
DOI: 10.1038/s41591-021-01549-6

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