Article
Improving reporting standards for polygenic scores in risk prediction studies.
Nature - 1 Mar 2021
Wand Hannah, Lambert Samuel A, Tamburro Cecelia, Iacocca Michael A, O'Sullivan Jack W, Sillari Catherine, Kullo Iftikhar J, Rowley Robb, Dron Jacqueline S, Brockman Deanna, Venner Eric, McCarthy Mark I, Antoniou Antonis C, Easton Douglas F, Hegele Robert A, Khera Amit V, Chatterjee Nilanjan, Kooperberg Charles, Edwards Karen, Vlessis Katherine, Kinnear Kim, Danesh John N, Parkinson Helen, Ramos Erin M, Roberts Megan C, Ormond Kelly E, Khoury Muin J, Janssens A Cecile J W, Goddard Katrina A B, Kraft Peter, MacArthur Jaqueline A L, Inouye Michael, Wojcik Genevieve L
Abstract excerpt
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association studies, can bridge the gap between initial discovery efforts and clinical applications for the estimation of disease risk using genetics. However, there is notable heterogeneity in the application and reporting of these risk scores, which hinders the translation of PRSs into clinical care. Here, in a collaboration between...
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