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Article

Diffuse midline glioma with extra central nervous system metastases in the pediatric, adolescent, and young adult population.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 7 Oct 2025

Giantini-Larsen Alexandra M, Garton Andrew L A, Rivera Maricruz, Han Rachael, Pisapia David J, Sait Sameer Farouk, Karajannis Matthias A, Greenfield Jeffrey P, Bilsky Mark H, Newman W Christopher, Souweidane Mark M

Abstract excerpt

Diffuse midline gliomas (DMG) are malignant infiltrative gliomas enriched in the pediatric population and characterized by loss of the H3 K27me3 epigenetic marker, most frequently via mutation of the H3-3A gene. Few cases of extra-central nervous system (CNS) DMG metastasis with redemonstrated H3-3A p.K28M (H3K27M) mutation in metastatic tissue are reported in the literature. Here, we report two such patients,...

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Identifiers

PMID: 41055765
DOI: 10.1007/s00381-025-06903-4
PMCID: PMC12504370

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TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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