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Extraneural Metastases of Diffuse Midline Glioma, H3 K27M-Mutant at Diagnosis: Case Report, Review of the Literature, and Identifying Targetable Alterations.

Journal of pediatric hematology/oncology - 1 Mar 2022

Lazow Margot A, Leach James L, Trout Andrew T, Breneman John C, Fouladi Maryam, Fuller Christine

Abstract excerpt

Extraneural metastases are rare in pediatric high-grade gliomas and little is known about the genomic profiles of tumors that disseminate beyond the central nervous system. We describe a pediatric patient with H3 K27M-mutant diffuse midline glioma of the brain and spine with biopsy-confirmed osseous metastases present at diagnosis and suspected metastatic parenchymal pulmonary disease. Several potentially...

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Astrocytoma
Brain Neoplasms
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Glioma
Histones

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PMID: 33974582
DOI: 10.1097/MPH.0000000000002189

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