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Article

Ribosomal biogenesis defects trigger subunit specific developmental checkpoints via TOR signaling and gap junction in C. elegans.

Developmental biology - 1 Jan 2026

Surya Agustian, Zhao Qiuxia, Voigt Brittney, Rangan Rekha, Cenik Elif Sarinay

Abstract excerpt

Ribosome biogenesis is critical for postembryonic development progression in Caenorhabditis elegans. Although maternally supplied ribosomes allow null mutants of ribosomal protein genes to complete embryogenesis, subsequent larval stages arrest if de novo ribosome production is compromised. Here, we compared null mutants in large (rpl-5, rpl-33) and small (rps-10, rps-23) ribosomal subunit genes with mutants...

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Identifiers

PMID: 41047111
DOI: 10.1016/j.ydbio.2025.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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