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Article

An antagonistic pleiotropic gene regulates the reproduction and longevity tradeoff

28 Apr 2022

Abstract excerpt

The antagonistic pleiotropy theory of aging proposes that genes enhancing fitness in early life limit the lifespan, but the molecular evidence remains underexplored. By profiling translatome changes in Caenorhabditis elegans during starvation recovery, we find that an open reading frame (ORF) trl-1 “hidden” within an annotated pseudogene significantly translates upon refeeding. trl-1 mutant animals increase brood...

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PMID: 35482917
DOI: 10.1073/pnas.2120311119

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