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Article

Substantial rDNA copy number reductions alter timing of development and produce variable tissue-specific phenotypes in C. elegans.

Genetics - 4 May 2023

Morton Elizabeth A, Hall Ashley N, Cuperus Josh T, Queitsch Christine

Abstract excerpt

The genes that encode ribosomal RNAs are present in several hundred copies in most eukaryotes. These vast arrays of repetitive ribosomal DNA (rDNA) have been implicated not just in ribosome biogenesis, but also aging, cancer, genome stability, and global gene expression. rDNA copy number is highly variable among and within species; this variability is thought to associate with traits relevant to human health and...

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PMID: 36919976
DOI: 10.1093/genetics/iyad039
PMCID: PMC10474940

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