Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis.

doi:10.1371/journal.pgen.1003279

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Article

Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis.

PLoS genetics - 1 Jan 2013

Boglev Yeliz, Badrock Andrew P, Trotter Andrew J, Du Qian, Richardson Elsbeth J, Parslow Adam C, Markmiller Sebastian J, Hall Nathan E, de Jong-Curtain Tanya A, Ng Annie Y, Verkade Heather, Ober Elke A, Field Holly A, Shin Donghun, Shin Chong H, Hannan Katherine M, Hannan Ross D, Pearson Richard B, Kim Seok-Hyung, Ess Kevin C, Lieschke Graham J, Stainier Didier Y R, Heath Joan K

Abstract excerpt

Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome biogenesis and translation initiation are deleterious to development and underlie a spectrum of diseases known collectively as ribosomopathies. Here, we describe a novel zebrafish mutant, titania (tti(s450)), which harbours a recessive lethal mutation in pwp2h, a gene encoding a protein component of the small subunit processome. The...

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PMID: 23408911
DOI: 10.1371/journal.pgen.1003279
PMCID: PMC3567153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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