Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.

Cell death & disease - 10 Apr 2014

Lee C-C, Tsai Y-T, Kao C-W, Lee L-W, Lai H-J, Ma T-H, Chang Y-S, Yeh N-H, Lo S J

Abstract excerpt

Human diseases of impaired ribosome biogenesis resulting from disruption of rRNA biosynthesis or loss of ribosomal components are collectively described as 'ribosomopathies'. Treacher Collins syndrome (TCS), a representative human ribosomopathy with craniofacial abnormalities, is attributed to mutations in the tcof1 gene that has a homologous gene called nopp140. Previous studies demonstrated that the dao-5...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Cell Nucleolus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromatin

Share to Chromosomal Proteins, Non-Histone

Share to Genes, Helminth

Share to Germ Cells

Share to Gonads

Share to RNA Polymerase I

Source

Open in PubMed Open full text

Identifiers

PMID: 24722283
DOI: 10.1038/cddis.2014.114
PMCID: PMC5424100

Genes

DAO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.PMID 24722283Read ↗

From Flies to Humans: A Conserved Role of CEBPZ, NOC2L, and NOC3L in rRNA Processing and TumorigenesisSemantic proximity Read ↗

Lack of CeR-2a RNA gene delays egg-laying onset in C. elegans mutant.Semantic proximity Read ↗

TDP-1 and FUST-1 co-inhibit exon inclusion and control fertility together with transcriptional regulation.Semantic proximity Read ↗

Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans.Semantic proximity Read ↗

Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis.Semantic proximity Read ↗

ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline.Semantic proximity Read ↗

Widespread cytoplasmic polyadenylation programs asymmetry in the germline and early embryoSemantic proximity Read ↗

A stress-dependent postembryonic role for the core CPA factor CFIM-1 in germline integritySemantic proximity Read ↗

POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4.Semantic proximity Read ↗

RNAi knockdown of Nopp140 induces Minute-like phenotypes in Drosophila.Semantic proximity Read ↗

Genome-wide analysis of germ cell proliferation in C. elegans identifies VRK-1 as a key regulator of CEP-1/p53Semantic proximity Read ↗

Genetic mutations in ribosomal biogenesis gene TCOF1 identified in human neural tube defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.